Northeast Wisconsin
  • Northeast Wisconsin
  • March 2016
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Red Clover — Trifolium pretense

Like peas and beans, red clover belongs to the family of plants called legumes. Red clover contains phytoestrogens — compounds similar to the female hormone estrogen. Historically, red clover has been used for cancer and respiratory problems, such as whooping cough, asthma and bronchitis. Currently, red clover is used as a traditional or folk remedy for menopausal symptoms, breast pain associated with menstrual cycles, high cholesterol, osteoporosis and symptoms of prostate enlargement.

The flowering tops of the red clover plant are used to prepare extracts available in tablets and capsules, as well as in teas and liquid forms.

What the science says

Several small studies of red clover for menopausal symptoms had mixed results; however, most of these studies had design flaws. A large clinical trial and several reviews of the research literature concluded that red clover had no significant beneficial effects on menopausal symptoms.

There is not enough scientific evidence to determine whether red clover is effective for any other health conditions.

NCCIH is studying red clover to learn more about its active components and how they might work in the body, including how red clover isoflavones may affect human prostate cells and the safety and effectiveness of red clover for menopausal symptoms.

Side effects and cautions

Red clover seems to be safe for most adults when used for short periods of time. No serious adverse effects have been reported.

Because red clover contains estrogen-like compounds, there is a possibility that its long term use would increase the risk of women developing cancer of the lining of the uterus. However, studies to date have been too brief (less than 6 months) to evaluate whether red clover has estrogen-like effects on the uterus.

Note: It is unclear whether red clover is safe for women who are pregnant or breastfeeding, or who have breast cancer or other hormone-sensitive cancers.

Tell all your health care providers about any complementary health approaches you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.


Source: “Herbs at a Glance: Red Clover.” National Center for Complementary and Alternative Medicine. https://nccih.nih.gov/health/redclover/ataglance.htm.

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